David de Gea – De Gea can expect to be considerably better in goal than he was on Sunday against Fulham.
Rafael – Despite some indifferent form this season, the Brazilian right-back can expect to retain his place on Wednesday night.
Chris Smalling – Smalling is enjoying a good period of form for his club and will be looking to continue that against Arsenal.
Nemanja Vidic – Vidic was culpable for United’s two goals at the weekend and has a point to prove against Arsenal after failing to commit his future to the club. Injuries to Phil Jones and Jonny Evans, as well as indifference from David Moyes towards Rio Ferdinand, should ensure the Serb’s spot.
Patrice Evra – The Frenchman will need to be on his guard against an Arsenal team who like to attack centrally. He will probably be called inwards from the flank to defend often, so will need high concentration.
Michael Carrick – Carrick is a shoe-in for central midfield against Arsenal.
Tom Cleverley – A labouring performance from Darren Fletcher against Fulham means he is unlikely to feature twice in a row. It will probably be the energetic Cleverley who partners Carrick on Wednesday, but if not Ryan Giggs may come in.
Ashley Young – After being substituted off at the weekend, Young will probably be fresh to start on Wednesday but Adnan Januzaj, Shinji Kagawa and Antonio Valencia will all be pushing for a place too.
Wayne Rooney – Rooney needs to get back to scoring ways if United are to find their way back into some decent league form.
Robin van Persie – The Dutchman will be looking to make it four goals out of four against Arsenal since he left them, and United certainly need him to score on Wednesday.
Ryan Giggs’ memorable moment T-shirt has been reduced to £9.99 for today only.
David Moyes has shown a tendency towards picking Young recently and perhaps deservedly so after some improved form. Unless fatigue or injuries have set in, the front six are set to remain the same from the match at the weekend apart from Fletcher.