Warren Joyce’s side was once again left without a recognised striker as James Wilson wasn’t fit enough to make the squad.
Tom Thorpe also didn’t recover in time and United’s injuries meant that only four players were named on the bench.
Despite plenty of possession for United in awful conditions, United lacked an attacking edge and didn’t really make Newcastle’s 15-year-old goalkeeper work.
James Weir, who gave a decent account of himself playing out of position on the left and at times up front, was taken down outside the box winning a free-kick. Andreas Pereira stepped up to take the set-piece but his shot was disappointingly well over the crossbar. Captain Reece James had the best chance of the first half with a strong shot that happened to be straight at Woolston.
Amos made his first save shortly before half-time from a Callum Roberts long range effort. However, despite the lack of chances Newcastle had in the first half, the Magpies took the lead early in the second half. Janko lost possession and Satko showed neat footwork to evade Ekangamene before sliding in Streete for the finish.
Josh Harrop later came on to replace Weir. Harrop looked lively and when he got on the ball he put pressure on the Newcastle defence by running at them and forcing them to give away free-kicks. Pereira came close with one of those free-kicks but a combination of Woolston and the crossbar denied him.
Ben Pearson almost set up Louis Rowley, who had moved into the centre-forward position, for an equaliser but his pass didn’t have enough power on it to make it to the far post. Later on, Reece James blasted the ball across the face of goal and Rowley launched himself towards it in the hope of retrieving something from the match but unfortunately, he wasn’t able to connect.
Amos made a fine save from Aarons to keep the deficit at only one goal as Newcastle continued to create more chances including a shot which hit the post. Jack Rudge came on for the final ten minutes to make his Under-21 league debut and had a shot late on but he couldn’t keep it down.
It was a disappointing defeat which ended United’s six game unbeaten run, losing to a Newcastle side who kept their first clean sheet this season.
Manchester United: Amos, Varela, McNair, Ekangamene, Rowley, Janko, R. James, Pearson, Rothwell, Weir (Harrop 54′), A. Pereira (Rudge 80′). Unused substitutes: Gollini, Goss.