David de Gea – The Spaniard has made the no. 1 jersey his own this season.
Rafael – A minor injury kept Rafael out of the game versus Bayern Munich but the Brazilian should be ready to come back in at St. James’ Park.
Phil Jones – With Rafael set to come back into the side, Jones can shift to his preferred position at centre-back.
Nemanja Vidic – With Jonny Evans and Chris Smalling still seemingly not quite at full fitness, Vidic is set to continue in defence against Newcastle.
Patrice Evra – Evra hasn’t appeared since the Manchester Derby but a minor injury to Alex Buttner is likely to see him return to the side on Saturday. The absence of Moussa Sissoko and Mathieu Debuchy should help United defensively on the left-side, although Evra will need to be wary of Hatem Ben Arfa.
Michael Carrick – After a first half rest last weekend, Carrick is set to start this Premier League fixture without too much fear of being overplayed.
Darren Fletcher – With Fletcher unlikely to start in Germany this week, he is set to play in central midfield on Saturday.
Ashley Young – Young has performed decently on the right side in the league recently, and therefore will probably start there again versus Newcastle.
Juan Mata – Champions League absences for Mata make him a certainty to start in the Premier League.
Danny Welbeck – In the absence of both Robin van Persie and Wayne Rooney, Danny Welbeck is likely to take on striker duties. He may well make way for Javier Hernandez at some point in the game with one eye on the Bayern match.
David Moyes is set to change three of his four attackers from the Bayern Munich match, with the three coming set to then make way again for the second leg this Wednesday. Wayne Rooney remains the constant.
Injuries would appear to more or less dictate the defensive line-up, with Carrick and Fletcher the likely pairing over Marouane Fellaini and Tom Cleverley in central midfield.