David de Gea – Manchester United’s player of the year is set to start in goal on Sunday.
Rafael – Despite being injured of late, Rafael may be fit to return for the last game of the season.
Rio Ferdinand – After being left out for the game against Hull, Ferdinand is set to return to the side against Southampton.
Nemanja Vidic – With Jonny Evans and Phil Jones injured, Vidic is set to start in his last ever game for United.
Patrice Evra – Alex Buttner started at left-back in midweek, meaning Evra is likely to come back in for United’s last game of the season.
Ashley Young – Young may be given a start on the right after Valencia was involved in midweek.
Darren Fletcher – Not involved in midweek, Fletcher is likely to come in ahead of Michael Carrick.
Tom Cleverley – Despite not featuring under Giggs since his first game, Cleverley may return into the centre of midfield for the final weekend of the season.
Danny Welbeck – Another recently overlooked by Giggs, Welbeck will probably feature against Southampton.
Juan Mata – Not involved in midweek, the Spaniard is set to return on Sunday.
Robin van Persie – Van Persie has only been given two substitute appearance by Giggs so far, so it wouldn’t be a surprise to see the Dutchman given a start in Giggs’ last game in charge.
It is guesswork to pick United’s team for the last game of the season; a meaningless fixture away to Southampton under interim manager Ryan Giggs who is becoming increasingly hard to predict.
Youngsters James Wilson, Tom Lawrence and Adnan Januzaj may yet be involved again in some capacity, but it is likely that Giggs may simply choose to rotate his team from those who started in midweek. Other youngsters such as Michael Keane and Ben Amos may also get another chance in the squad.