David de Gea – Manchester United’s No.1 will start against his native Spanish opposition.
Chris Smalling – If Smalling has sufficiently recovered from his injury on tour, he will start this game.
Jonny Evans – Evans should complete the line-up for Van Gaal’s first choice back three.
Ander Herrera – Herrera may make up one of three Spanish players to start against the team from Valencia in what will be his debut at Old Trafford.
Darren Fletcher – Fletcher will likely captain the side once again.
Juan Mata – The former Valencia man will be relishing this fixture.
Wayne Rooney – Rooney has had a good pre-season and will be hoping that continues.
Javier Hernandez – With doubts remaining about Danny Welbeck’s fitness, it can be assumed that Chicharito will start this friendly.
Louis van Gaal may well select his strongest side against Valencia in preparation for Saturday’s Premier League opener but expect wholesale changes at half-time to keep the team fresh.