David de Gea – Manchester United’s No.1 will emphasise his claim on that spot by starting the competitive season in goal.
Chris Smalling – Smalling is an obvious selection on Saturday on the right-side of central defence.
Phil Jones – Jones joins Smalling as an essential pick in a defence bereft of experienced players due to transfers and injuries.
Darren Fletcher – Fletcher will provide the experienced head in a young team.
Ander Herrera – New signing Herrera is set to start in his first competitive game for the Red Devils.
Juan Mata – Mata will be relishing the start of a new season in his favoured central attacking role.
Wayne Rooney – United’s new captain will start on Saturday.
Javier Hernandez – Natural striker Hernandez is set to get the nod ahead of Adnan Januzaj up front with Danny Welbeck still injured and Robin van Persie ruled out by his manager.
Despite injury and squad depth problems, Van Gaal is set to remain with the 3-4-1-2 formation that he has set the side up with during pre-season.
If the Dutch manager opts for more experience than the line-up above he may well start Darren Fletcher in defence with Tom Cleverley taking his place in midfield, but this is unlikely.