Manchester United: De Gea, Valencia, Smalling, Evans, Rojo, Herrera, Blind, Di Maria, Rooney, Young, Falcao
Subs: Lindegaard, McNair, Carrick, Fellaini, Mata, Januzaj, Wilson
Sunderland: Pantilimon, Reveillere, van Aanholt, Brown, O’Shea, Cattermole, Larsson, Gomez, Johnson, Wickham, Defoe
Subs: Mannone, Bridcutt, Fletcher, Graham, Coates, Vergini, Watmore
Ander Herrera start for the second Premier League game in succession after impressing, and scoring, against Swansea City last weekend.
Radamel Falcao also gets his chance to impress once again with Robin van Persie seemingly missing for several weeks, he starts up front on his own as United revert to a 4-2-3-1 system.
Luke Shaw is missing from the starting line-up not for the first time, Marcos Rojo moves to left-back as he did against Burnley with Jonny Evans coming in to partner Phil Jones in defence. Ashley Young also returns to the XI as Louis van Gaal looks to beat Sunderland with width.