Defeat to Arsenal at Old Trafford – something not seen in the Premier League since 2006 – would leave Man United eight points behind the top four places.
Here is the full confirmed squad for what is a crucial game for Jose Mourinho and United.
De Gea, Romero, Grant
Dalot, Valencia, Darmian, Smalling, Bailly, Rojo
Fred, Pogba, Fellaini, McTominay, Lingard, Herrera, Matic, Pereira, Mata
Martial, Rashford, Lukaku