Pogba has been sidelined since picking up an ankle injury during Manchester United’s 1-1 draw with Southampton prior to the international break.
The Norwegian confirmed on Friday that the trio would not recover in time for the trip to the London Stadium.
Pogba, Shaw and Martial all out of @ManUtd trip to West Ham. Solskjaer 'hopeful' Daniel James will be fit.
— Simon Stone (@sistoney67) September 20, 2019
Daniel James, on the other hand, is a minor doubt for the game, with Solskjaer noting that he was “hopeful” of the youngster returning from a knock picked up against Leicester.
The unavailability of Martial (and potentially James) opens up space for Mason Greenwood, who scored a wonderful first senior goal against Astana, to have a crack at West Ham’s back four.
Losing Pogba is a massive blow, although it does provide Fred with another opportunity to play the propulsive role in United’s hitherto sticky midfield. The Brazilian will need to be positive with his passing if United are to hit West Ham with their counter-attacking approach.