David de Gea: Despite comments saying he wants to use Anders Lindegaard, David Moyes is likely to stick with his number one against Southampton.
Rafael: The Brazilian looks to have found some form and consistency after an injury at the beginning of the season.
Jonny Evans: Youth and pace could be vital against a Southampton team who play a very high pressing game, therefore the Northern Irishman may be included.
Nemanja Vidic: With it still unclear whether Rio Ferdinand has fully recovered from a groin injury, the Serbian captain is likely to start this tough fixture.
Patrice Evra: Evra has been a constant focal point in United’s attacking moves under Moyes and could be crucial in helping to break down a stubborn Saints defence.
Nani: The unpredictability of Nani could favour a start for the Portuguese against the good Southampton back-line on Saturday, baring in mind also the long journey back for Antonio Valencia from international duty.
Marouane Fellaini: Despite injury concerns with his wrist, Fellaini featured for Belgium on international duty and therefore may be used against Southampton. Should Cleverley recover from an injury he may also feature as may Ryan Giggs, Anderson or Phil Jones. It is an unpredictable position for this particular game.
Adnan Januzaj: After his superb debut start against Sunderland, it would be strange if Januzaj was not rewarded with another start, particularly as competition for his place is not currently compelling.
Wayne Rooney: Rooney continued his excellent form with England and will be looking to progress further on Saturday.
Robin van Persie: Van Persie rediscovered his scoring touch on international duty to become the Netherlands’ all-time top goalscorer. If he and Rooney can continue their international week form they will be almost unstoppable on Saturday.
David Moyes has recently used Wayne Rooney and Robin van Persie in a more linear two-man partnership recently, something that may continue against Southampton as it creates space for the floating Nani and Januzaj to cut inside and create behind the front two.
Michael Carrick‘s midfield partner is unclear due to injuries, and it could be any one of several players. Meanwhile central defence is another position with which Moyes will have to make some tough selection calls. It would be unusual to see any of the experienced players who didn’t go away on international duty (Ferdinand, Vidic, Giggs) to not feature at all, however.