David de Gea – De Gea will be looking to keep a third consecutive Champions League clean sheet on Wednesday.
Rafael – After stating online that he is fully fit and ready to play, Rafael can be expected to return to the right-back berth against Leverkusen.
Jonny Evans – With Nemanja Vidic not fully recovered from his concussion injury yet, Evans is a near certain starter.
Chris Smalling – Smalling may well partner Evans on Wednesday given Rio Ferdinand’s tendency to not be able to play two games in a short period of time.
Patrice Evra – Despite scoring, Evra did not play to his highest level on Sunday against Cardiff and will be looking to rectify that in Germany.
Antonio Valencia – Having started in all of United’s Champions League games so far, Valencia could be vital again in this game, particularly in the absence of any serious competitor to his position at the moment.
Tom Cleverley – Cleverley is another not performing to his highest level at the moment but lack of midfield options suggest he will start again on Wednesday. David Moyes may well leave Phil Jones out of the starting XI with a view to him starting at White Hart Lane this coming Sunday.
Ryan Giggs – The suspension to Marouane Fellaini and the fact Giggs only appeared from the bench against Cardiff suggest the Welshman will be start agaisnt Leverkusen. It would also be his third European start in a row.
Shinji Kagawa – Despite getting a bruised foot from international duty, Kagawa will most likely make his fourth Champions League start this season on the left-hand side after he took part in full training today.
Javier Hernandez – In a toss up between Danny Welbeck and Chicharito, the Mexican should be given the nod on Wednesday.
The inclusion of Shinji Kagawa also provides an additional fluidity to the United attack, something that was seen in the reverse fixture against Leverkusen earlier on in the season. Watch out for Ryan Giggs’ potential lofted balls to match the intelligent runs of Hernandez should both start.