Jones was sidelined with an injury he picked up on international duty this week while Vidic was still trying to recover from concussion he suffered against Arsenal a few weeks ago.
Without Jones in the side against Cardiff, United’s midfield struggled to impose themselves and while Marouane Fellaini had an improved performance, Cleverley didn’t manage to complete a single tackle in the match.
Van Persie has not trained so isn’t in line to return against Leverkusen but with Wayne Rooney, Javier Hernandez and Danny Welbeck all fit, there should be ample cover for him.
Michael Carrick was also absent despite returning to training ahead of schedule last week.
The importance of the game against Leverkusen shouldn’t be underestimated. If we win, qualification is secure. If we lose, then we have to get a result against Shakhtar Donetsk in the last game of the group stage and will need other results to go our way to finish top of the group.
United are likely to get a very tough round of 16 match if they finish second so David Moyes will want a strong result in Germany tomorrow.