David de Gea – This game at home to Shakhtar will be De Gea’s tenth consecutive start for David Moyes.
Rafael – With Chris Smalling set to miss out with injury, Rafael can be expected to start at right-back on Tuesday night.
Rio Ferdinand – Due a game, Ferdinand is likely to play at centre-back especially considering Nemanja Vidic’s absence from training on Monday.
Jonny Evans – Rested last week against Everton, Jonny Evans should be ready to start this Champions League fixture.
Alex Buttner – After missing training on Monday, Patrice Evra may have to miss this big European tie meaning Buttner would be likely to step in.
Antonio Valencia – Left out of the starting XI on Saturday, United’s most reliable winger can be expected to come back in on Tuesday.
Phil Jones – David Moyes indicated he has one eye on the game next Sunday against Aston Villa, a game Ryan Giggs may be saved for. This leaves it as a toss up between Phil Jones and Marouane Fellaini in midfield (unless they get partnered) with Jones seeming a more reliable and fitter option at the moment.
Tom Cleverley – Cleverley put in an improved performance on Saturday and provided Jones compliments him well on Tuesday, he could be chosen to partner his English counterpart again.
Danny Welbeck – If Patrice Evra is indeed absent on Tuesday, United will need a strong option on the left-wing hence the hard-working Welbeck.
Shinji Kagawa – After playing Robin van Persie for longer than intended on Saturday, the Dutchman will most likely not be started again so soon. This may mean Moyes reverts back to the Kagawa-Rooney attacking combination he has favoured in recent games.
Wayne Rooney – Having received a rest due to suspension at the weekend, United’s best player should be raring to go against Shakhtar.
Van Persie is certainly in need of a rest after Saturday’s outing and Nemanja Vidic, Chris Smalling and Patrice Evra are all also doubts for this game. Moyes’ main selection dilemmas thus come in the form of deciding a central midfield pairing, an attacking partner for Wayne Rooney, and a left-winger.