David de Gea – After starting once again in the League Cup on Wednesday evening, it is hard to envisage a situation where De Gea will not be picked in goal by David Moyes.
Rafael – This is set to be a sixth consecutive start for the Brazilian, although he can expect to be rested for at least one of the upcoming games over the festive period.
Jonny Evans – It would appear to be a case of Evans plus one other in United’s central defence at the moment.
Phil Jones – After a midweek stint in midfield, Jones should be moved back to defence for this game.
Patrice Evra – A fabulous goal in midweek will have boosted the Frenchman after an indifferent display versus Aston Villa last weekend. Like Rafael, he can also expect at least one game out of the starting XI at some point this Christmas.
Antonio Valencia – A third start in a week is on the cards for Valencia, especially after his thrilling performance last weekend.
Tom Cleverley – Cleverley has really started to find some form of late and will be eager to continue that on Saturday.
Ryan Giggs – Being used more than usual in the absence of Michael Carrick, Giggs will probably come back into the team fresh after being rested for the League Cup tie in midweek.
Adnan Januzaj – Another rested in midweek, the young Belgian will be expected to come back into the side on Saturday, although Ashley Young will be pushing him for a place after a good midweek performance.
Wayne Rooney – Rooney has a chance of featuring after injury according to David Moyes and if he is fully fit, then he has to start. If he is deemed not fit to start then Javier Hernandez will probably take his place or Shinji Kagawa.
Danny Welbeck – Welbeck will be looking for a further boost and continued form up front as he is set to start a third game in a row in the central striker position.
Moyes’ attacking selections may well depend on whether Rooney is fit or not. If he is fit, it is an identical set-up to last weekend can be expected. If not, then there may be some significant reshuffling.
A high line in defence will probably be necessary in order to combat West Ham’s sizeable midfield hence the youthful Evans and Jones (or maybe Chris Smalling) are favourites to start.
Left-wing is perhaps the hardest position to predict with Januzaj staking a claim, Young showing improved form and Kagawa being back in the squad. Nani, however, has been ruled out with injury.