David de Gea – Spanish Dave will be a busy boy against Manchester City.
Rafael – He needs to improve his temperament having been rash in the past few games but he’ll start at right-back.
Phil Jones – Jones is United’s only definitely fit centre-back.
Jonny Evans – Evans is the most likely of United’s injured defenders to make a comeback for Tuesday night.
Patrice Evra – Rested at the weekend, the Frenchman will be brought back into the starting line-up against City.
Michael Carrick – Carrick is a certainty to start on Tuesday, hopefully in midfield.
Marouane Fellaini – Perhaps Fellaini’s best performance in a United shirt was against West Ham at the weekend, probably ensuring his place for this huge tie.
Antonio Valencia – Valencia’s good showing in the Champions League last week may have earned him a start on the right side for the match.
Juan Mata – After a good showing at No. 10 at the weekend, Mata will start there again.
Danny Welbeck – Welbeck’s good performance on the left against Olympiacos, combined with a rest from the starting XI at the weekend, mean he should start there against United’s rivals.
Wayne Rooney – With Welbeck on the left and Van Persie injured, Rooney will lead the line on Tuesday.
Rotation means Welbeck and Valencia will probably come in for Shinji Kagawa and Ashley Young, with Darren Fletcher missing out on a second game in four days.
If United do not have enough centre-backs fit, then expect Michael Carrick to drop back there with Tom Cleverley or Ryan Giggs coming in to midfield.