David de Gea – Manchester United’s No.1 will emphasise his claim on that spot by starting the competitive season in goal.
Chris Smalling – Smalling is an obvious selection on Saturday on the right-side of central defence.
Phil Jones – Jones joins Smalling as an essential pick in a defence bereft of experienced players due to transfers and injuries.
Darren Fletcher – Fletcher will provide the experienced head in a young team.
Ander Herrera – New signing Herrera is set to start in his first competitive game for the Red Devils.
Juan Mata – Mata will be relishing the start of a new season in his favoured central attacking role.
Wayne Rooney – United’s new captain will start on Saturday.
Despite injury and squad depth problems, Van Gaal is set to remain with the 3-4-1-2 formation that he has set the side up with during pre-season.
If the Dutch manager opts for more experience than the line-up above he may well start Darren Fletcher in defence with Tom Cleverley taking his place in midfield, but this is unlikely.