Rojo was left out of United’s squad to face Liverpool last weekend by Van Gaal as a precaution but has not been deemed fit enough to return today.
As for Fellaini, it will put an end to a series of consecutive starts for him under Van Gaal.
“Rafael is not injured,” Van Gaal explained yesterday.
“He was already fit last week, but I have to select and I have to compare.
“When I have more players fit, I have to select. You will have to wait and see, of course. I have to compare. Rafael? I can take him in the 18. Rojo? No. We have five injuries and one [Marouane Fellaini] is ill, so they are not coming up. Rojo has a rectus femoris [thigh] injury.”
Current reports suggest Darren Fletcher is set to deputise in Fellaini’s absence which also indicates Michael Carrick will once again play in defence.