The Dutchman suffered an ankle injury in the 2-1 defeat to Swansea in February and has been sidelined ever since.
Louis van Gaal’s side have coped well in van Persie’s absence, registering impressive victories over Tottenham Hotspur and Liverpool in recent weeks.
Meanwhile, the 31-year-old is stepping up his rehabilitation with United physio Matt Radcliffe following a period at home in Holland.
If back in the team, van Persie would be keen to repeat his heroics of 2012 when he scored a late winner against City to swing the title back in United’s favour.
Second-placed City are currently two points ahead of United in fourth but there is a growing confidence from fans that the team can overtake Manuel Pellegrini’s men.
Van Persie will also be raring to go as he will be entering the final year of his contract next season. Given his poor form this term, it remains to be seen whether or not United will offer him a new deal.