It was likely that United would be unchanged following the 4-2 win over Manchester City so the injuries have left the squad in tatters.
Van Gaal lamented the injuries and conceded that he doesn’t have many options when it comes to replacing the duo.
Speaking about the injuries, van Gaal said: “It is the worst scenario.
“Marcos and Phil can both play left central defender and Jonny Evans is also suspended so I do not have many choices.”
Van Gaal turned to the pair after the team went through a similar injury crisis earlier in the campaign and they both performed admirably having been thrown in at the deep end. Whoever starts in defence, they will have their hands full as it looks more than likely that Didier Drogba will play up front for Jose Mourinho’s side.