Shaw received lengthy treatment on the pitch early on in Holland following a crunching challenge from Hector Moreno.
The youngster was eventually stretched off and it looks like he will be out of action for a while.
Shaw, tweeting before the game had even finished, insisted he will “come back stronger”:
@SouthamptonFC thank you , you don't know how much you as a club mean to me , thank you so much I really appreciate it
Thank you everyone for your messages , words can't describe how gutted I am , my road to recovery starts now, I will come back stronger.
Shaw has been one of United’s standout players this season and his injury comes as a sickening blow.
He had finally been kicking on following an indifferent campaign last year and the setback will be difficult to recover from. The hope is that the injury won’t keep him out of action for too long but it’s safe to say that fans are preparing themselves for the worst.