Shaw suffered a double leg break in the reverse fixture against PSV earlier this term, while Valencia recently underwent surgery on a foot problem.
Carrick is recovering from a knock picked up while on international duty with England and Herrera hobbled off in the game against Watford last weekend. Jones also picked up an injury at Vicarage Road.
LVG confirms Shaw, Valencia, Carrick, Jones and Herrera are out.
— Paul Hirst (@hirstclass) November 24, 2015
The recent injuries to Herrera and Jones, in particular, were worrying to see for United fans.
Supporters are desperate for Herrera to impress in the starting XI as he seems to still be out of favour with van Gaal despite some encouraging displays.
Jones, meanwhile, has been in and out of the side throughout the course of the campaign due to niggling injuries here and there. The hope is that the pair are not out for too long as United head into the busy Christmas schedule.