The Portuguese once again made eight changes to the side that featured against Celta Vigo last week for Sunday’s 2-1 defeat to Tottenham Hotspur.
Mourinho has, on several occasions, emphasised the need to rotate his squad ahead of the Europa League final, with just 15 senior players available in the wake of a tumultuous injury crisis over a busy April period.
And the 54-year-old, speaking ahead of the clash at Saint Mary’s, confirmed that he would once again field a heavily changed squad.
“I have to build some teams with the minimum of conditions to fight for the result,” he said. “We lost against Arsenal 2-0, we fought for the result. We lost 2-1 against Tottenham and we fought for the result and we want to fight for the result.”
“I don’t want to field a team where people have a feeling that we are not fighting for the result. We are fighting for the result.
“I am going to rotate people. As I was saying Blind will not be playing against Southampton and Fellaini will because he’s not played the last three matches and these are examples of trying not to accumulate when people have to play because we do not have other players and I cannot put four or five kids all together in the fire. I cannot do that to the kids.
“Martial’s fine and he’s one of the guys for who it’s very important to play 90 minutes. Smalling, Jones, Mata, it’s very important for them to play 90 minutes.”
The likes of Eric Bailly and Jesse Lingard, alongside Daley Blind, will most likely sit out of the game against Claude Puel’s men after featuring against both Celta and Spurs in the space of a few days. Paul Pogba will remain absent following the passing of his father over the weekend.
The likes of Marcus Rashford, Ander Herrera and Henrikh Mkhitaryan are all set to start after receiving rests over the weekend. Axel Tuanzebe, Demetri Mitchell and Scott McTominay could all feature as well after being withdrawn from the Under 23 side that claimed a 3-2 win over Spurs on Monday night.