Youngsters Mason Greenwood and James Garner, on the other hand, could be in line for senior debuts after receiving a call-up to the first team.
Man United’s trip to the Mestalla comes with no pressure after Jose Mourinho’s men secured qualification to the knockout stages against Young Boys on match-day five.
Here is the full squad which flew to Spain on Tuesday afternoon.
Young, Valencia, Bailly, Jones, Rojo
Fred, Andreas, Herrera, McTominay, Garner, Pogba, Lingard, Fellaini, Mata
Lukaku, Rashford, Greenwood