The Frenchman continues to nurse a foot problem sustained against Southampton, while Wan-Bissaka is suffering from a back problem.
However, Diogo Dalot and Angel Gomes have returned to the squad ahead of both players potentially starting in the Netherlands.
Here is the full travelling squad ahead of a crucial away game for Ole Gunnar Solskjaer‘s men.
De Gea, Romero, Grant
Dalot, Lindelof, Maguire, Tuanzebe, Rojo, Williams
McTominay, Matic, Fred, Garner, Andreas, Mata
Lingard, Gomes, James, Chong, Rashford, Greenwood