Varane pulled a hamstring just 38 minutes into Tuesday’s Champions league tie with Atalanta and Pogba is serving the second of a three match ban.
In all likelihood given his recent form, Pogba would not have been selected even if he was available. His performance on Tuesday was well below par.
Varane is more of a blow at the moment, although Victor Lindelof is expected to return in defence, which will ease the pain of losing him.
Manager Ole Gunnar Solskjaer could play the 3-5-2 formation that worked so well against Spurs last weekend. He started with it on Tuesday as well but was forced to abandon it when Varane limped off.
Maguire’s form, on the other hand, has been awful but we do not expect Solskjaer to drop his captain, especially as the Frenchman is unavailable.
David de Gea is expected to keep his place in goal despite also disappointing on Tuesday. Solskjaer will be hoping that it was a one-off as he had been in superb form this season until then.
Up front, Edinson Cavani will probably be recalled after having been rested on Tuesday, although he did play 21 minutes from the bench. Cristiano Ronaldo will, of course, be alongside him, giving the 70-year-old front line another run out.
With Solskjaer’s job still hanging in the balance, this could prove to be a crucial team selection and it will almost certainly be one that is cautious and that includes the players he believes he can count on most.
With all that in mind, this is our predicted XI: