A home tie against Swiss minnows who cannot qualify from Champions League Group F should mean that Manchester United can field a rotated team tomorrow at Old Trafford.
However, Young Boys do still have something to play for, as a win could see them qualify for the Europa League by virtue of finishing third in the group.
United will top the Group no matter what because of their record over Villarreal so their Round of 16 draw will be easier, avoiding the likes of Bayern Munich and, depending on results, Real Madrid.
It is therefore a golden opportunity for new boss Ralf Rangnick to look at some of his squad players in action for the first time and to give them valuable minutes on the pitch.
It does therefore seem likely that some big names will be rested.
Our predicted XI assumes that none of the above will be available.
If the manager sticks to the 4-2-2-2 he employed against Palace, Nemanja Matic could replace either Fred or Scott McTominay – probably the latter, as Fred has been playing in more of a box-to-box role recently.
With all that in mind, here is our predicted XI for tomorrow’s game: