| Date | Opponent | Stadium | Result | ||
| Tour 2012 | 18 July | AmaZulu FC | Moses Mabhida | 0-1 | Report | Photos |
| Tour 2012 | 21 July | Ajax Cape Town | Cape Town | 1-1 | Report | Photos |
| Tour 2012 | 25 July | Shanghai Shenhua | Shanghai | 0-1 | Report | Photos |
| Tour 2012 | 5 August | Valerenga | Ulleval | 0-0 | Report | Photos |
| Tour 2012 | 8 August | FC Barcelona | Ullevi | 0-0 (0-2) | Report | Photos |
| Tour 2012 | 11 August | Hannover 96 | AWD Arena | 3-4 | Report | Photos |
| BPL | 20 August | Everton | Goodison Park | 1-0 | Report | Photos |
| BPL | 25 August | Fulham | Old Trafford | 3-2 | Report | Photos |
| BPL | 2 September | Southampton | St Mary’s | 2-3 | Report | Photos |
| BPL | 15 September | Wigan | Old Trafford | 4-0 | Report | Photos |
| UEFA CL | 19 September | Galatasaray | Old Trafford | 1-0 | Report | Photos |
| BPL | 23 September | Liverpool | Anfield | 1-2 | Report | Photos |
| LC | 26 September | Newcastle | Old Trafford | 2-1 | Report | Photos |
| BPL | 29 September | Tottenham | Old Trafford | 2-3 | Report | Photos |
| UEFA CL | 2 October | CFR Cluj | Dr Constantin Radulescu | 1-2 | Report | Photos |
| BPL | 7 October | Newcastle United | Sports Direct Arena | 0-3 | Report | Photos |
| BPL | 20 October | Stoke City | Old Trafford | 4-2 | Report | Photos |
| UEFA CL | 23 October | SC Braga | Old Trafford | 3-2 | Report | Photos |
| BPL | 28 October | Chelsea | Stamford Bridge | 3-2 | Report | Photos |
| COC | 31 October | Chelsea | Stamford Bridge | 5-4 | Report | Photos |
| BPL | 3 November | Arsenal | Old Trafford | 2-1 | Report | Photos |
| UEFA CL | 7 November | SC Braga | Estadio Municipal | 1-3 | Report | Photos |
| BPL | 10 November | Aston Villa | Villa Park | 2-3 | Report | Photos |
| BPL | 17 November | Norwich City | Carrow Road | 1-0 | Report | Photos |
| UEFA CL | 20 November | Galatasaray | Turk Telekom Arena | 1-0 | Report | Photos |
| BPL | 24 November | QPR | Old Trafford | 3-1 | Report | Photos |
| BPL | 28 November | West Ham United | Old Trafford | 1-0 | Report | Photos |
| BPL | 1 December | Reading | Madjeski Stadium | 3-4 | Report | Photos |
| UEFA CL | 5 December | CFR Cluj | Old Trafford | 0-1 | Report | Photos |
| BPL | 9 December | Manchester City | Etihad Stadium | 2-3 | Report | Photos |
| BPL | 15 December | Sunderland | Old Trafford | 3-1 | Report | Photos |
| BPL | 23 December | Swansea | Liberty Stadium | 1-1 | Report | Photos |
| BPL | 26 December | Newcastle United | Old Trafford | 4-3 | Report | Photos |
| BPL | 29 December | West Brom | Old Trafford | 1-0 | Report | Photos |
| BPL | 1 January | Wigan Athletic | DW Stadium | 0-4 | Report | Photos |
| FA CUP | 9 January | West Ham | Upton Park | 2-2 | Report | Photos |
| BPL | 13 January | Liverpool | Old Trafford | 2-1 | Report | Photos |
| FA CUP | 16 January | West Ham | Old Trafford | 1-0 | Report | Photos |
| BPL | 20 January | Tottenham Hotspur | White Hart Lane | 1-1 | Report | Photos |
| FA CUP | 26 January | Fulham | Old Trafford | 4-1 | Report | Photos |
| BPL | 28 January | Southampton | Old Trafford | 2-1 | Report | Photos |
| BPL | 2 February | Fulham | Craven Cottage | 1-0 | Report | Photos |
| BPL | 10 February | Everton | Old Trafford | 2-0 | Report | Photos |
| UEFA CL | 13 February | Real Madrid | Santiago Bernabeu | 1-1 | Report | Photos |
| FA CUP | 18 February | Reading | Old Trafford | 2-1 | Report | Photos |
| BPL | 23 February | QPR | Loftus Road | 0-2 | Report | Photos |
| BPL | 2 March | Norwich City | Old Trafford | 4-0 | Report | Photos |
| UEFA CL | 5 March | Real Madrid | Old Trafford | 1-2 | Report | Photos |
| FA CUP | 10 March | Chelsea | Old Trafford | 2-2 | Report | Photos |
| BPL | 16 March | Reading | Old Trafford | 1-0 | Report | Photos |
| BPL | 30 March | Sunderland | Stadium of Light | 0-1 | Report | Photos |
| FA CUP | 1 April | Chelsea | Stamford Bridge | 1-0 | Report | Photos |
| BPL | 8 April | Manchester City | Old Trafford | 1-2 | Report | Photos |
| BPL | 14 April | Stoke City | Britannia Stadium | 0-2 | Report | Photos |
| BPL | 17 April | West Ham | Upton Park | 2-2 | Report | Photos |
| BPL | 22 April | Aston Villa | Old Trafford | 3-0 | Report | Photos |
| BPL | 28 April | Arsenal | Emirates Stadium | 1-1 | Report | Photos |
| BPL | 4 May | Chelsea | Old Trafford | 0-1 | Report | Photos |
| BPL | 12 May | Swansea | Old Trafford | 2-1 | Report | Photos |
| BPL | 19 May | West Brom | The Hawthorns | 5-5 | Report | Photos |
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